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This quantity surveys the chemistry and heterocyclic syntheses of aminomethylenemalonates and their cyclic sters. Early studies during this box simply touched on sure points of the similar chemistry. this is often the 1st in-depth systematic therapy of the topic. the fabric is of specific significance in medicinal chemistry as derivatives of aminomethylene malonates are key intermediates within the synthesis of antimalarial brokers. The literature reviewed has ended in the invention of nalidixic acid and its derivatives, norfloxacin and ciprofloxacin, in addition to the hot quinolones which are energetic opposed to AIDS-related Legionella spp.

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