The speedy speed of evolution in domino, or cascade-based ameliorations has revolutionized the perform of chemical synthesis for the construction of common items, designed molecules, and pharmaceuticals.
"Science of Synthesis: functions of Domino differences in natural Synthesis" explores the subject completely and systematically, serving because the foundation for useful purposes and destiny examine. The 2-volume set provides the state-of-the-art when it comes to layout, procedure, and experimental strategies, resulting in a number of occasions being comprehensive inside a unmarried response vessel. The content material is geared up by way of the center form of response used to begin the development, be it a pericyclic response, a metal-mediated transformation, radical chemistry, or an acid-induced cascade between many others.
Volume 1 covers polyene/cation-pi cyclizations, metathesis, radical, and metal-mediated reactions, and non-radical skeletal rearrangements.
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